HIV-1 genotypic resistance: automated sequence analysis and interpretation
نویسندگان
چکیده
منابع مشابه
The HIVdb system for HIV-1 genotypic resistance interpretation.
The Stanford HIV Drug Resistance Database hosts a freely available online genotypic resistance interpretation system called HIVdb to help clinicians and laboratories interpret HIV-1 genotypic resistance tests. These tests are designed to assess susceptibility to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI), protease inhibitors and integrase inhibitors. The HIVd...
متن کاملHIV-1 genotypic drug resistance interpretation rules - 2009 Spanish guidelines.
Interpreting the results of drug resistance tests for HIV-1 is one of the most difficult tasks for both clinicians and virologists. There are many amino acid changes in viral proteins influencing the susceptibility to specific drugs, causing loss of activity or conversely hypersusceptibility. Moreover, the results of interactions derived from complex mutational patterns are difficult to predict...
متن کاملPredictive value of HIV-1 genotypic resistance test interpretation algorithms.
BACKGROUND Interpreting human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance test results is challenging for clinicians treating HIV-1-infected patients. Multiple drug-resistance interpretation algorithms have been developed, but their predictive value has rarely been evaluated using contemporary clinical data sets. METHODS We examined the predictive value of 4 algorithms at ...
متن کاملWeb resources for HIV type 1 genotypic-resistance test interpretation.
Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many drug-resistance mutations, and they arise in complex patterns that cause varying levels of drug resistance. In addition, HIV-1 exists in vivo as a virus population containing many ge...
متن کاملDiscrepancies of HIV-1 reverse transcriptase resistance interpretation of insertions and deletions between two genotypic algorithms.
BACKGROUND Bioinformatics algorithms have been developed for the interpretation of resistance from sequence submission, which supports clinical decision making. This study evaluated divergences of the interpretation of the genotyping in two commonly used algorithms, using sequences with indels of reverse transcriptase genes. METHODS Sequences were obtained from virus RNA of patients failing h...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 1998
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/14.10.886